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*Our group's paper "Total Synthesis of (–)-Lycoposerramine-S" was highlighted in Synfacts. (Jan 17, 2013)
*Our group's paper "2-Pyridone Synthesis Using 2-(Phenylsulfinyl)acetamide" is available online in Organic Letters. (Dec 21, 2012)
*Our group's paper "Modified McFadyen-Stevens Reaction for a Versatile Synthesis of Aliphatic/Aromatic Aldehydes: Design, Optimization, and Mechanistic Investigations" is available online in Chemical Science. (Dec 17, 2012)
*Our group's paper "Activity-Dependent Proteolytic Cleavage of Neuroligin-1" is available online in Neuron. (Oct 25, 2012)
*Our group's paper "Total Synthesis of (–)-Lycoposerramine-S" is available online in Angewandte Chemie International Edition. (Oct 16, 2012)
*Our group's paper "Total Synthesis of (–)-Isoschizogamine" was highlighted in Synfacts. (Sep 21, 2012)
*Our group's paper "Synthetic Studies on Chartelline C: Stereoselective Construction of the Core Skeleton" is available online in Angewandte Chemie International Edition. (Aug 03, 2012)
*Our group's paper "Total Synthesis of (–)-Lemonomycin" is available online in Chemistry - A European Journal. (Aug 02, 2012)
*Our group's paper "Total Synthesis of (–)-Isoschizogamine" is available online in Journal of the American Chemical Society. (Jul 14, 2012)
*Our group's paper "Synthetic Studies toward Ecteinascidin 743 (Trabectedin)" is available online in Synthesis. (Jul 06, 2012)
*Our group's paper "Total Synthesis of (–)-Anisatin" was highlighted in Synfacts. (Jun 26, 2012)
*Our group's paper "Convenient Synthesis of α-Diazoacetates from α-Bromoacetates and N,N'-Ditosylhydrazine: Preparation of Benzyl Diazoacetate" is available online in Organic Syntheses. (May 28, 2012)
*Our group's paper "Efficient Synthesis of Oxime Using O-TBS-N-Tosylhydroxylamine: Preparation of (2Z)-4-(Benzyloxy)but-2-enal Oxime" is available online in Organic Syntheses. (May 28, 2012)
*Our group's paper "Total Synthesis of All the Amathaspiramides" was highlighted in Synfacts. (May 22, 2012)
*Our group's paper "Total Synthesis of Gelsemoxonine" is aveilable online in Pure and Applied Chemistry. (May 09, 2012)
*Ren Takeuchi was awarded a Student Best Presentation Award at the 132nd Annual Meeting of the Pharmaceutical Society (Sapporo, Japan). Title: "Synthetic Studies on Asymmetric Synthesis of Epidithiopiperazinedione Skeleton" (Apr 25, 2012)
*Yoshitake Nishiyama (G3) was awarded a Student Best Presentation Award at the 132nd Annual Meeting of the Pharmaceutical Society (Sapporo, Japan). Title: "Synthetic Studies on Lepenine" (Apr 25, 2012)
*Our group's paper "A Practical Preparation of Highly Versatile N-Acylpyrroles from 2,4,4-Trimethoxybutan-1-amine" is available online in Organic Letters. (Apr 03, 2012)
*Dr. Yokoshima (Associate Professor) has moved to Graduate School of Pharmaceutical Science, Nagoya University. (Apr 02, 2012)
*Dr. Shimokawa (Assistant Professor) has moved to Graduate School of Pharmaceutical Science, Nagoya University. (Apr 02, 2012)
*Our group's paper "Total Synthesis of (–)-Anisatin" is available online in Organic Letters. (Feb 28, 2012)
*Our group's paper "Total Syntheses of All the Amathaspiramides" is available online in Angewandte Chemie International Edition. (Jan 27, 2012)
The paper was selected as a Hot Paper by editors. (Feb 03, 2012)
*Our group's paper "Total Synthesis of Gelsemoxonine" was highlighted in Synfacts. (Jan 05, 2012)
*Dr. Satoshi Yokoshima (Associate professor) received "The Pharmaceutical Society of Japan Award for Young Scientists '12". (Nov 21, 2011)
*Our group's paper "A Practical Synthesis of (-)-Kainic Acid " is available online in Synthesis. (Oct 25, 2011)
*Our group's paper "Total Synthesis of Gelsemoxonine" is available online in Journal of the American Chemical Society. (Oct 14, 2011)
*The paper of our group and Department of Neuropathology and Neuroscience (Graduate School of Pharmaceutical Sciences, Univ. of Tokyo)"Phenylpiperidine-type γ-secretase modulators target the transmembrane domain 1 of presenilin 1" is available online in EMBO Journal. (Oct 14, 2011)
*Takuya Higo (G3) was awarded a Student Poster Prize at the 23rd International Congress on Heterocyclic Chemistry (Glasgow, Scotland). Title: "Synthetic Studies on Sarain A" (Aug 29, 2011)
*Fumiki Kawagishi (G3) was awarded a Student Poster Prize at the 23rd International Congress on Heterocyclic Chemistry (Glasgow, Scotland). Title: "Total Synthesis of Ecteinascidin 743" (Aug 29, 2011)
*Our group's paper "Total Synthesis of (–)-Histrionicotoxin" is available online in Organic Letters. (Jul 27, 2011)
*Our group's paper "Copper-Mediated Aryl Amination: In Situ Generation of an Active Copper(I) Species" is available online in Synlett. (Jul 15, 2011)
*Our group's paper "Total Synthesis of Tryprostatins A and B" is available online in Tetrahedron. (Jun 2, 2011)
*Our group's paper "Total Synthesis of (–)-Salinosporamide A" is available online in Organic Letters. (May 17, 2011)
*The paper of our group and Department of Neuropathology and Neuroscience (Graduate School of Pharmaceutical Sciences, Univ. of Tokyo)"BACE1 Activity Is Modulated by Cell-Associated Sphingosine-1-Phosphate" is available online in The Journal of Neuroscience. (May 04, 2011)
*Our group's paper "Total Synthesis of (－)-Conophylline and (－)-Conophyllidine" is available online in Angewandte Chemie International Edition. (15 Apr 2011)
*Dr. Yokoshima has gotten his promotion to Associate Professer. Congratulations! (Apr 1, 2011)
*Our group's paper "A Practical Synthesis of (－)-Kainic Acid" is available online in Organic Letters. (22 Mar 2011)
*Our group's paper "Concise Total Synthesis of (+)-Lyconadin A" is available online in Journal of the American Chemical Society. (15 Dec 2010)
*Our group's paper "Total Synthesis of Tryprostatins A and B" is available online in Angewandte Chemie International Edition. (30 Oct 2010)
*Our group's paper "Total Synthesis of (－)-Morphine" is available online in Chemistry - An Asian Journal. (20 Aug 2011)
*Our group's paper "Synthesis of the optically active key intermediate of FR901483" is available online in Tetrahedron Letters. (27 Jul 2010)
*Our group's paper "Total Synthesis of (+)-Manzamine A"" target="_blank">"" is available online in Journal of the American Chemical Society. (17 Jul 2010)
*Our group's paper "Total Synthesis of (－)-Mersicarpine" is available online in Journal of the American Chemical Society. (12 Jan 2010)
*Our group's paper "Development of photoaffinity probes for γ-secretase equipped with a nitrobenzenesulfonamide-type cleavable linker" is available online in Bioorganic & Medicinal Chemistry Letters. (15 Dec 2009)
*Our group's paper "Total Synthesis of (－)-Huperzine A" is available online in Organic Letters. (29 Oct 2009)
*Our group's paper "Synthesis of Lysergic Acid Methyl Ester via the Double Cyclization Strategy" is available online in Synlett. (04 Apr 2009)
*Our group's paper "Synthetic Studies toward (+)-Lysergic Acid: Construction of the Tetracyclic Ergoline Skeleton" is available online in Heterocycles. (19 Jan 2011)
*Our group's paper "Total Synthesis of (－)-Serotobenine" is available online in Journal of the American Chemical Society. (20 Nov 2008)
*Our group's paper "A Practical Synthesis of (−)-Oseltamivir" is available online in Tetrahedron. (21 Oct 2008)
*Our group's paper "Total Synthesis of (±)-Morphine" is available online in Heterocycles. (26 Sep 2008)
*Our group's paper "Palladium-catalyzed Coupling of N-Heteroaryl Sulfides with Organozinc Reagent" is available online in Heterocycles. (02 Sep 2008)
*Our group's paper "Mild Debenzylation of Aryl Benzyl Ether with BCl3 in the Presence of Pentamethylbenzene as a Non-Lewis-Basic Cation Scavenger" is available online in Synlett. (22 Jul 2008)
*Our group's paper "Synthetic Studies on (+)-Manzamine A: Stereoselective Synthesis of the Tetracyclic Core Framework" is available online in Organic Letters. (03 Jul 2008)
*Our group's paper "Synthesis of Eudistomin C and E: Improved Preparation of the Indole Unit" is available online in Organic Letters. (23 May 2008)
*Our group's paper "A Simple Chiral Template for the Synthesis of Fuctionalized alpha-Arylglycine Derivatives" is available online in Heterocycles. (9 May 2008)
*Our group's paper "O-TBS-N-tosylhydroxylamine: A Reagent for Facile Conversion of Alcohols to Oximes" is available online in Organic Letters. (Apr 30 2008)
*Our group's paper "Total Synthesis of (-)-Kainic Acid via Intramolecular Michael Addition: A Second-Generation Route" is available online in Organic Letters. (Apr 11 2008)
*Please refer to an excellent review on Professor Tohru Fukuyama in Columbia Chemistry Synthesis Literacy Group (Apr 2, 2008)
*Dr. Yokoshima has gotten his promotion to Lecturer. Congratulations! (Apr 1, 2008)
*2008-Academic year has started. (Apr 1, 2008)
*Our group's latest paper "Stereocontrolled Total Synthesis of (-)-Kainic Acid" is qualified as 3rd Most-Accessed Articles: Full-year, 2007. Congratulations! (Mar 31, 2008)
*Our group's latest paper "Synthesis of (+)-Vinblastine and Its Analogues is qualified as 1st Most-Accessed Articles: Most-Accessed Articles: October-December, 2007. Congratulations! (Mar 31, 2008)
The major research efforts of our group are directed toward total synthesis of complex natural products with interesting biological activities. Current total synthesis targets of our laboratory include potent antitumor compound ecteinascidin 743, discorhabdins, lysergic acid, tetrodotoxin, kainic acid, lemonomycin, UCS1025A, naphthyridinomycin, mitomycins to mention a few. In order to achieve these total syntheses, we have also extensively investigated new synthetic methodologies and new protecting groups. Methodologies recently developed along these lines include synthesis of amines using nitrobenzenesulfonyl groups, indole synthesis by radical cyclization of o-alkenylphenylisocyanides or o-alkenythioanilides, and transformation of thiol esters to aldehydes or ketones. Our laboratory has recently completed the total syntheses of the following natural products: (+)-gelsemine, (±)-vincadifformine, (-)-tabersonine, HO-416b, (±)-catharanthine, (+)-K252a, phomoidride B, lipogrammistin-A, eudistomin C, (+)-vinblastine, duocarmycin A, leustroducsin B, ecteinascidin 743, and ephedradine A.
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